Enterovirus D68 most commonly causes advanced respiratory symptoms such as persistent cough, wheezing and progressive shortness of breath. Initially, symptoms from this virus may emerge in a typical fashion with fever, rash, nausea, vomiting or diarrhea. However, the most significant aspect of this virus is the advanced respiratory illness that it causes in children. It can also have a greater impact on children with underlying respiratory issues like asthma or if they are immunocompromised due to congenital heart disease or other chronic ailments that may impact their immune system.